Injectable Biologic Formulation Development

The field has advanced considerably in recent years, but a number of key challenges remain. by Raymond E Peck, CEO of VxP Biologics Because injectable biologics are introduced directly into the body’s tissues, these formulations must be extraordinarily free from contamination of every kind. This requirement sets a high bar for the manufacturing of injectables. [...]

By |2018-02-08T16:41:27-05:00February 6th, 2018|Manufacturing, Research & Development|0 Comments

Flow Cytometry

This powerful technique enables rapid identification and sorting of cells, streamlining the manufacture of many biologic pharmaceuticals. by Raymond E Peck, CEO of VxP Biologics In the manufacture of many types of biologics, flow cytometry is a crucial tool for identifying, analyzing and sorting cells. This technique can provide a wide range of data points [...]

By |2018-02-07T09:35:44-05:00October 23rd, 2017|Manufacturing, Research & Development|0 Comments

Vero Cell Platform Technology

This cell development platform has proven effective in the creation of a number of viral vaccines. by Susan Thompson, Technical Director at VxP Biologics Recent years have witnessed a significant amount of innovation in technologies for the development of novel vaccines. These technologies include new vector systems for delivering attenuated vaccines, recombinant technologies for generating [...]

By |2018-02-07T09:33:45-05:00October 1st, 2017|Research & Development|0 Comments

Upstream and Downstream Process Optimization is Essential to Cost Containment in Biologics Manufacturing

Improvements throughout the pipeline bring greater biologic yields, as well as higher quality. by Raymond E Peck, CEO of VxP Biologics Improvements throughout the pipeline bring greater biologic yields, as well as lower costs. Bioprocessing is the production of natural or genetically manipulated cells (or other organic parts). In the field of biologic pharmaceuticals, bioprocessing [...]

By |2018-04-05T13:01:46-04:00September 22nd, 2017|Analytical, Manufacturing|0 Comments

Vector Development

The creation, production and storage of viral vectors all pose highly unusual challenges. by Susan Thompson, Technical Director at VxP Biologics Traditional viral vaccines use attenuated or inactivated forms of viruses to trigger and “train” the body’s immune responses. In recent years, however, pharmaceutical developers have also begun to use viruses as vectors to deliver [...]

By |2018-02-07T09:34:35-05:00September 19th, 2017|Manufacturing|0 Comments

BSL-3 Biologic Development

Advances in Biological Safety Level 3 technology offer advantages for agile biologic developers. by Raymond E Peck, CEO of VxP Biologics Many types of biologics include live populations of organisms, some of which may be highly infectious in active form. Vaccines, in particular, often contain deadly bacteria and viruses in live but attenuated forms. The [...]

By |2018-02-07T09:36:41-05:00September 14th, 2017|Manufacturing|0 Comments

Biologics Process Development

As the biologics market expands, developers need support from expert contractors. by Raymond E Peck, CEO of VxP Biologics A growing number of pharmaceutical development companies are partnering with contract manufacturing organizations (CMOs) to meet the global demand for biologics. This investment comes with good reason: as of 2016, the global biopharmaceutical market was valued [...]

By |2018-02-07T09:36:42-05:00August 11th, 2017|Manufacturing|0 Comments

New Investments and Approvals Spur the Development of Biologics

Although still expensive to develop and produce, large molecules are rapidly taking over. by Susan Thompson, Technical Director at VxP Biologics For most of the previous century, much of pharmaceutical research focused on the development of small-molecule “blockbuster” drugs, which treated a wide variety of diseases for a great number of patients, and could thus [...]

By |2018-02-07T09:33:52-05:00June 18th, 2017|Manufacturing, Research & Development|0 Comments

Five Crucial Areas of Concern in Any GLP Lyophilization Process

Although lyophilization (freeze-drying) is a costly, time-consuming process, it offers a number of major advantages over simpler dosage forms. by Raymond E Peck, CEO of VxP Biologics Tablets and capsules can create problems for patients with nausea or difficulty swallowing; syringes can carry risk of infection; and even certain drugs administered from vials can take [...]

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